Dr. Michael Kaplitt, MD – New York, NY

Overview of Dr. Kaplitt

Dr. Kaplitt combines surgical expertise with advanced training in state-of-the-art stereotactic techniques to provide patients with effective, minimally invasive treatments for degenerative disorders, including Parkinson’s disease, essential tremor, and dystonia. He also uses these methods to provide novel treatments for psychiatric disorders such as obsessive-compulsive disorder as well as for experimental treatment of major depression and drug addiction. In addition, he is an expert in the use of implanted devices for the treatment of medication-resistant complex pain, spasticity and adult hydrocephalus.

Dr. Kaplitt is also an expert in various surgical therapies for trigeminal neuralgia as well as novel therapies for more complex craniofacial pain. He is recognized for his contributions by leading medical and patient associations, and has repeatedly been named to Castle Connolly’s America’s Top Doctors and New York Metro Top Doctors and regularly appears on the New York Super Doctors list. He is a member of the Executive Committee of the American Society for Stereotactic and Functional Neurosurgery, the society for physicians who specialize in this type of surgery, and he is on the editorial board of the journal Stereotactic and Functional Neurosurgery, the primary international journal in this area.

Dr. Kaplitt has pioneered human gene therapy for neurodegenerative disorders, having performed as a student the first rodent study that used the adeno-associated virus (AAV) vehicle for gene transfer to the brain. He performed the world’s first human gene therapy procedure for Parkinson’s disease, and more recently helped to guide the first successful randomized, double-blind, sham-controlled trial of this experimental treatment, which was the first positive trial of this kind for gene therapy in any brain disorder. He is also pioneering the development of novel deep brain stimulation treatments for psychiatric diseases, including refractory drug addiction.

Education & Training

• New York Presbyterian Hospital (Cornell Campus)Chief Residency, Neurological Surgery, 1999 - 2000

• New York Presbyterian Hospital (Cornell Campus)Residency, Neurological Surgery, 1996 - 2000

• Rockefeller UniversityPost-Doctoral Fellowship, Biochemical Genetics and Metabolism, 1995 - 1998

• New York Presbyterian Hospital (Cornell Campus)Internship, Neurological Surgery, 1995 - 1996

• Rockefeller UniversityPost-Doctoral Fellowship, Neurobiology and Behavior, 1993 - 1995

• Weill Cornell MedicineClass of 1995

Certifications & Licensure

• FL State Medical License 2022 - Present

• NY State Medical License 1998 - 2025

• CT State Medical License 2022 - 2024

• American Board of Neurological Surgery Neurological Surgery

Awards, Honors, & Recognition

• America's Top Doctors Castle Connolly
• CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2013
• Super Doctor SuperDoctors.com
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Clinical Trials

Publications & Presentations

PubMed

• Phosphoglycerate kinase is a central leverage point in Parkinson's Disease driven neuronal metabolic deficits.

  Alexandros C Kokotos, Aldana M Antoniazzi, Santiago R Unda, Myung Soo Ko, Daehun Park, David Eliezer, Michael G Kaplitt, Pietro De Camilli, Timothy A Ryan> ;Biorxiv. 2023 Oct 10

• Cranial MRgFUS intraprocedural diffusion and T2 imaging and comparison with postablation lesion size and location.

  Edward J Ebani, Sara Strauss, Charlene Thomas, Arindam RoyChoudhury, Michael G Kaplitt, J Levi Chazen> ;Journal of Neurosurgery. 2023 Oct 1
• 10 citations

  Focused ultrasound-mediated blood-brain barrier opening in Alzheimer's disease: long-term safety, imaging, and cognitive outcomes.

  Ali R Rezai, Manish Ranjan, Marc W Haut, Jeffrey Carpenter, Pierre-François D'Haese, Rashi I Mehta, Umer Najib, Peng Wang, Daniel O Claassen, J Levi Chazen, Vibhor Kri...> ;Journal of Neurosurgery. 2023 Jul 1
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Journal Articles

• Clinical Quantitative Susceptibility Mapping (QSM): Biometal Imaging and Its Emerging Roles in Patient Care  

  Gary M Brittenham, Apostolos John Tsiouris, Lawrence Tanenbaum, Ajay Gupta, Martin R Prince, Jonathan W Weinsaft, Susan A Gauthier, Brian H Kopell, Michael G Kaplitt, ..., Journal of Magnetic Resonance Imaging

Authored Content

• Safe and Stable Noninvasive Focal Gene Delivery to the Mammalian Brain Following Focused Ultrasound RelatedApril 2018

• Safe and Stable Noninvasive Focal Gene Delivery to the Mammalian Brain Following Focused Ultrasound RelatedApril 2018

Press Mentions

• A Promising Trial Targets a Genetic Risk for Alzheimer’sDecember 2nd, 2022

• LEXEO Therapeutics to Present New Clinical Data from Its Investigational Gene Therapy LX1001 for APOE4-Associated Alzheimer’s Disease at the 29th European Society of Gene & Cell Therapy Annual MeetingOctober 5th, 2022

• Can Ultrasound Help Treat Alzheimer’s?March 7th, 2022

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Grant Support

• Gene Therapy for Huntington’s DiseaseNIH/NINDS2010–2015

Professional Memberships

Hospital Affiliations

Insurance Accepted

• Aetna Choice POS II
  Aetna HMO
  BCBS Blue Card PPO
  CIGNA HMO
  CIGNA Open Access
  CIGNA PPO
  Empire BCBS HMO
  Empire BCBS PPO
  GHI PPO
  

  Great West PPO
  HIP of New York - Select PPO
  Humana ChoiceCare Network PPO
  MagnaCare PPO
  MVP Healthcare PPO
  Oxford Health Freedom
  Oxford Health Liberty
  United Healthcare - Direct Choice Plus POS
  United Healthcare - Direct Options PPO
  

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